Appleseed Ex Machina, also known as E.X. Machina (エクスマキナ, Ekusu Makina) in the original version, is a 2007 Japanese animated CG science fiction film and is the sequel to the 2004 Appleseed film. Synopsis: It is up to a battle hardened former soldier and her cyborg comrade to prevent a deranged scientist from uniting humanity in a collective consciousness.

References:
https://en.wikipedia.org/wiki/Appleseed_Ex_Machina