I Am Legend is a 2007 American post-apocalyptic action thriller film loosely based on the 1954 novel of the same name by Richard Matheson. Synopsis: Set in New York City after a vaccine, which was originally created to cure cancer, has wiped out most of mankind, leaving a US Army virologist as the last human in New York, not counting vicious nocturnal mutants.

References:
https://en.wikipedia.org/wiki/I_Am_Legend_(film)