Set two years after the events of Spider-Man, the film finds Peter Parker struggling to manage both his personal life and his duties as Spider-Man, which affects his civilian life dramatically. Meanwhile, Dr. Otto Octavius becomes a diabolical villain after a failed experiment kills his wife and leaves him neurologically fused to mechanical tentacles. Spider-Man must stop him from successfully recreating the experiment, which threatens to blow up the city, while dealing with a subconscious desire to stop being Spider-Man that is stripping him of his powers. It is the second installment in the Sam Raimi directed Spider-Man trilogy.

References:
https://en.wikipedia.org/wiki/Spider-Man_2