Set shortly after the events of Spider-Man 2, as Peter Parker prepares his future with Mary Jane Watson, he bonds with an extraterrestrial symbiote, bringing out his anger while facing three villains: Uncle Ben's true killer, Flint Marko, who becomes the Sandman after a freak accident; Harry Osborn, who seeks to avenge his father; and Eddie Brock, a rival photographer who becomes Venom after acquiring Peter's symbiote. It is the third and final installment in the Sam Raimi directed Spider-Man trilogy.

References:
https://en.wikipedia.org/wiki/Spider-Man_3